Proponents of memetics as described in the Journal of Memetics (out of print since 2005[23] ) – Evolutionary Models of Information Transmission believe that 'memetics' has the potential to be an important and promising analysis of culture using the framework of evolutionary concepts. Keith Henson in Memetics and the Modular-Mind (Analog Aug. 1987)[24] makes the case that memetics needs to incorporate evolutionary psychology to understand the psychological traits of a meme's host.[25] This is especially true of time-varying, meme-amplification host-traits, such as those leading to wars.[26][27]

DiCarlo ([year needed]) has developed the idea of 'memetic equilibrium' to describe a cultural compatible state with biological equilibrium. In "Problem Solving and Neurotransmission in the Upper Paleolithic" (in press[clarification needed]), diCarlo argues that as human consciousness evolved and developed, so too did our ancestors' capacity to consider and attempt to solve environmental problems in more conceptually sophisticated ways. Understood in this way, problem solving amongst a particular group, when considered satisfactory, often produces a feeling of environmental control, stability, in short—memetic equilibrium. But the pay-off is not merely practical, providing purely functional utility—it is biochemical and it comes in the form of neurotransmitters. The relationship between a gradually emerging conscious awareness and sophisticated languages in which to formulate representations combined with the desire to maintain biological equilibrium, generated the necessity for memetic equilibrium to fill in conceptual gaps in terms of understanding three very important aspects in the Upper Paleolithic: causality, morality, and mortality. The desire to explain phenomena in relation to maintaining survival and reproductive stasis, generated a normative stance in the minds of our ancestors—Survival/Reproductive Value (or S-R Value).

Houben (2014) has argued on several occasions that the exceptional resilience of Vedic ritual and its interaction with a changing ecological and economic environment over several millennia can be profitably dealt with in a ‘cultural evolution’ perspective in which the Vedic mantra is the ‘meme’ or unit of cultural replication.[28] This renders superfluous attempts[by whom?] to explain the phenomenon of Vedic tradition in genetic[clarification needed] terms.[29] The domain of Vedic ritual should be able[clarification needed] to fulfil to a large extent the three challenges posed to memetics by B. Edmonds (2002 and 2005).[30]